Sleep test predicts dementia in older adults

first_imgDementia is a growing problem for people as they age, but it often goes undiagnosed. Now investigators at Harvard-affiliated Massachusetts General Hospital (MGH) and Beth Israel Deaconess Medical Center have discovered and validated a marker of dementia that may help clinicians identify patients who have the condition or are at risk of developing it. The findings are published in JAMA Network Open.The team recently created the Brain Age Index (BAI), a model that relies on artificial intelligence and a large set of sleep data to estimate the difference between a person’s chronological age and the biological age of their brain when computed through electrical measurements (with an electroencephalogram, or EEG) during sleep. A higher BAI signifies deviation from normal brain aging, which could reflect the presence and severity of dementia.“The model computes the difference between a person’s chronological age and how old their brain activity during sleep ‘looks,’ to provide an indication of whether a person’s brain is aging faster than is normal,” said senior author M. Brandon Westover, investigator in the Department of Neurology at MGH and director of Data Science at the MGH McCance Center for Brain Health. “This is an important advance, because before now it has only been possible to measure brain age using brain imaging with magnetic resonance imaging, which is much more expensive, not easy to repeat, and impossible to measure at home,” added Elissa Ye, the first author of the study and a member of Westover’s laboratory. She noted that sleep EEG tests are increasingly accessible in non-sleep laboratory environments, using inexpensive technologies such as headbands and dry EEG electrodes.To test whether high BAI values obtained through EEG measurements may be indicative of dementia, the researchers computed values for 5,144 sleep tests in 88 individuals with dementia, 44 with mild cognitive impairment, 1,075 with cognitive symptoms but no diagnosis of impairment, and 2,336 without dementia. BAI values rose across the groups as cognitive impairment increased, and patients with dementia had an average value of about four years older than those without dementia. BAI values also correlated with neuropsychiatric scores from standard cognitive assessments conducted by clinicians before or after the sleep study.“Because quite feasible to obtain multiple nights of EEG, even at home, we expect that measuring BAI will one day become a routine part of primary care, as important as measuring blood pressure,” said co-senior author Alice D. Lam, an investigator in the Department of Neurology at MGH. “BAI has potential as a screening tool for the presence of underlying neurodegenerative disease and monitoring of disease progression.” The Daily Gazette Sign up for daily emails to get the latest Harvard news.last_img read more

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Bottom on Top! Eight Pics of Something Rotten! Star Brian d’Arcy James Winning a SAG Award!

first_img Star Files Billy Crudup, Brian d’Arcy James & Mark Ruffalo at the 22nd Annual Screen Actor Guild Awards (Photo: Jason Merritt/Getty Images) Yup, that’s Broadway’s Brian d’Arcy James, who won a Screen Actors Guild Award on January 30 at the Shine Auditorium in Hollywood! (Photo by Kevin Winter/Getty Images)Hi Brian! (Photo by Kevin Winter/Getty Images)He won it for his first leading film role, playing Boston Globe journalist Matt Carroll in the acclaimed Spotlight. (Photo by Frazer Harrison/Getty Images)All seven of the film’s stars won in Outstanding Performance by the Cast of a Motion Picture category. (Photo by Frazer Harrison/Getty Images)So James got to pose with all his fancy Hollywood friends and their new green man trophies. Oh hey, Broadway vets Billy Crudup, Mark Ruffalo, John Slattery and Liev Schreiber! Hope to see you on the boards soon, Rachel McAdams and Michael Keaton! (Photo by Rich Polk/Getty Images)The Spectacular Seven beat out the casts of Beasts of No Nation, The Big Short, Straight Outta Compton and Trumbo for the win! (Photo by Jason Merritt/Getty Images)As the cameras snapped away, James was beaming with excitement and now looking at the pics, we can’t help but beam with Broadway pride. (Photo by Rich Polk/Getty Images)Can’t wait to see what you do next, Brian. But for now, we’re happy we’ve got you on Broadway. (Photo by Frazer Harrison/Getty Images)Is this Bottom on top or what? Related Shows Something Rotten! Show Closed This production ended its run on Jan. 1, 2017 View Comments OMG. Did you hear?! Did you see it on TV?? Brian d’Arcy Jameslast_img read more

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NMC’s Peter Hofstetter Named CEO of the Year

first_imgPeter Hofstetter, Chief Executive Officer of Northwestern Medical Center, was awarded QHR’s first annual “CEO of the Year” award during their annual meeting in Brentwood, TN, Thursday, June 5, 2008. Peter was chosen from among more than 150 of his hospital CEO peers across the U.S. for this great honor.QHR is one of the quiet partners in NMC’s success. Dating back to the hospital merger in the late 1970’s, NMC has enjoyed the benefits of management, consulting, and education services provided by QHR, formerly known as Quorum Health Resources. Jim Horrar, President of QHR, presented Peter with his award, saying When one considers the fundamental aspects of a leader, many qualities come to mind including strategic foresight, enthusiasm, emotional intelligence, effective communication, determination, and loyalty (just to name a few). Peter Hofstetter personifies these qualities as CEO for Northwestern Medical Center (NMC) in St. Albans, Vermont and has been doing so for many years. Horrar added, Northwestern Medical Center has thrived under Peter’s leadership for the past 15 years always ranked as one of the top performers statewide and in the company for financial, customer service, and quality. NMC has strong days cash on hand and operating margin, an updated facility, little debt, and a positive culture making it one of the top places to work in northern Vermont.Peter has always maintained an open door policy to employee and physician concerns which has fostered this open and inclusive environment. He leads by example as his employees know they will never be asked to do something that he wouldn’t do himself, with ethics and integrity serving as the cornerstones of his value system, he said.John Casavant, President of NMC’s Board of Directors, agrees with Horrar’s comments, adding, Peter is certainly deserving of this recognition from QHR, and we applaud their decision to recognize him with their first annual CEO of the Year Award. We are very fortunate to have such a tremendous professional leading our hospital, as well as sharing his vision, energy, and support to many organizations in our community and throughout the state. I’m proud of NMC’s work, in large part because of Peter’s dedication to doing the right thing for our hospital and our community.Northwestern Medical Center, nestled at the top of Fairfield Street in St. Albans, Vermont, provides nationally award winning health care, in an intimate, collaborative setting. For more information about NMC, visit us online at www.northwesternmedicalcenter.org(link is external).last_img read more

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Top 20 Adventure Sports Films and Videos

first_imgVideo fills a pivotal role in the world of adventure sports. There are few things that get me as fired up as watching good adventure sport films or video clips before and after shredding with buddies. Here are the top 20 videos that I find myself queuing up time and again.TOP 10 FILMS10. Pretty Faces (Ski)Executed from start to finish by women, this film expresses the joy of being a skier girl and provides inspiration to the aspiring youth.9. Grand Inga Project (Kayak)The best videos provide historical context and heart-pounding action. This expedition to the largest whitewater in the world does both.8. Touching the Void (Drama)This story of devotion, tragedy, inner demons, and perseverance truly defies belief.7. The Art of Flight (Snowboard)This spectacular documentary was one of the first to open up the incredible capabilities of high frame rate cameras.6. Seasons (Mountain Bike)Digging into the personalities of downhill and freeride mountain biking, this video truly shows the soul of the sport.5. The River Wild (Drama)One of my childhood favorites! This high budget Hollywood production shows the allure of “the river” while also providing the audience with an interpersonal thriller.4. Into the Wild (Drama)Christopher McCandless plus John Krakauer plus Eddie Vedder equals a beautiful story. Not everyone fits into the machine.3. Life Cycles (Mountain Bike)The feature brought something fresh and unique to the adventure sports cinematography world—the most notable being the visual effect of changing seasons.2. Riding Giants (Surf)This fascinating history of big wave surfing is unique in its ability to draw any viewer into the stories and the power of the ocean.1. McConkey (Ski / BASE)Shane McConkey must be one of the most influential figures in any outdoor sport, ever. He changed the game in everything from the attitude of pro skiers, to the direction of elite competition, to the possibility of taking to the air via BASE jumping. Shane also paid the ultimate price, passing away in 2009 on a ski BASE with his best friend, JT Holmes. This film tells the story of Shane’s life, and is the single most impressive compilation of stunts that I have ever seen… and they’re all by one person.TOP 10 VIDEOS10. Jet Ski Barrel (Surf)Mother Nature vs. technology…we know which is more powerful.9. McGarry Rampage (Mountain Bike)Kelly McGarry gives a raw look into the pinnacle of mountain biking… the Red Bull Rampage. Everything from the breathing, the knife ridge riding, and the incredible gaps is gripping.8. Church Two (Mountain Bike)Southeast represent! Brandon Blakely and Evan Voss express their unique styles on and off the bike.Church Two from ZfH Productions on Vimeo.7. Kai Lenny 4 in 1 (SUP / Surf / Windsurf / Kiteboard)Kai is the next generation waterman, and he showcases his abilities in this epic multisport session at Jaws.6. Danny Hart Worlds (Mountain Bike)Incredible riding skill… even better announcing!5. Imaginate (Mountain Bike)This Danny MacAskill video wins the creativity award hands down… we’re all kids at heart4. Palouse Falls First D (Kayak)This 189-foot beast is the perfect waterfall, and Tyler Bradt’s audacious first descent and world record has not been exceeded since.3. One of Those Days 2 (Ski)All I can say about this is that it’s mind-blowing and superhuman. I want to be this guy.2. JP Auclair Street (Ski)JP Auclair shows that you can have a blast and shred no matter the setting.1. Dream (Kayak)Ben Marr and Skip Armstrong express their joy for kayaking and the inner insecurities of all of us in this highly entertaining piece.DREAM from NRS Films on Vimeo.last_img read more

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Maine-Endwell recognizes seniors with cap and gown pick up party

first_imgAccording to school officials, a celebration will be held May 26 and 27 for seniors. Families will be able to make a stop at a car decorating station and students will have the opportunity to get their photos taken in front of the district’s blue and gold backdrop. They said seniors can pick up their caps, gowns, and class t-shirts by having their family members drive up and stay in their cars. Students will be divided by alphabetical order. This will be at the high school at 750 Farm to Market Rd. in Endwell at the back of the building and it will be from 9 to 11:15 a.m. and then again from 11:30 a.m. and 1:45 p.m. on both days. ENDWELL (WBNG) — The Maine-Endwell school district will hold a cap and gown pick up party while social distancing this week.last_img read more

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Cheers and Jeers: Wednesday

first_imgCheers and Jeers for Wednesday, November 4, 2020Note: November 4th is National Stress Awareness Day.  To inform motorists around you who might not know this, drive up behind them, honk your horn several times and shout, “Hey, asshole! If you weren’t so stupid you’d know it’s National Stress Awareness Day!”  They’ll appreciate the reminder and will probably respond with a friendly wave.  Thanks. Together we can make a difference. —Mgt.- Advertisement – –By the Numbers:Bideninauguration.jpg77 days!!! (We hope.)Days ’til inauguration day: 77- Advertisement – Number of times the Trump campaign ended up stranding his cultists on the tarmac at airports in Georgia, Nebraska, Pennsylvania and North Carolina after his super-spreader events: 4Number of Trump’s promised second-round $1,200 relief checks, $200 Medicare “gift cards,” or covid vaccine doses the American people received by election day: 0Original and current number of chambers in the International Space Station, which has been inhabited for 20 years as of last Monday: 3 / 16–Mid-week Rapture Index: 180 (including 4 apostasies and 1 Covid-19 vaccine “mark of the beast.”) Soul Protection Factor 24 lotion is recommended if you’ll be walking amongst the heathen today.–Puppy Pic of the Day: Cue the theme from Mission: Impossible…–JEERS to our profoundly broken country. This election should’ve ended last night in a landslide for the candidate of truth, fact, and decency, even with a tidal wave of mail-in votes pending. I really don’t know what to say. In all likelihood Biden will still be our next president. But, holy cow, the chunk of our fellow countrymen who choose hate and ignorance over the alternative is not what I signed up for when I popped out onto this planet 56 years ago. How’s that Mars colony comin’?CHEERS to inevitable conclusions. Soon-to-be-ex-President (we hope) Donald Trump called “Obamagate” the greatest scandal in history, a witch hunt smear campaign hoax that tried to sabotage his soon-to-be-ex-presidency (we hope) “worse than anyone else in the history of the country.” It was to be one of his big “October surprises” that would destroy Joe Biden. Well, the investigation is over and, sure enough, it was the worst scandal ever and Barack Obama reported to Leavenworth Prison this morning to be fingerprinted and ha ha ha of course not:Top prosecutors in the so-called Durham probe into the origins of the Russiagate investigation have reportedly found “no evidence” to support the foundational theory that spawned the investigation—namely, that Obamagate occurred and that Barack Obama himself needed to be punished for it.Obamagatetansuit.jpegGuilty as hell. According to a New York Magazine story relying on anonymous sources “familiar with the probe,” U.S. Attorney for the District of Connecticut John Durham has come up empty-handed and is growing increasingly frustrated with Attorney General Bill Barr overdevelopments in the investigation—or, rather, the lack thereof.The lesson is clear: a good fake scandal is hard to find.CHEERS to #1. Here’s another little election milestone from the archives: it was 96 years ago today, back in 1924, when Nellie Tayloe Ross became the first elected woman governor in U.S. history.  She ran in Wyoming in the wake of her husband, Gov. William Ross’s death from appendicitis, but was careful to avoid any public display of ambition for the job as that wouldn’t be ladylike.  Her modest agenda soon mushroomed, oddly enough, into one of great ambition: [R]equiring cities, counties, and school districts to have budgets; stronger state laws regulating banks; exploration of better ways to sell Wyoming’s heavy crude oil; earmarking some state mineral royalties for school districts; obtaining more funds for the university; improving safety for coal miners; protecting women in industrial jobs; and supporting a proposed amendment to the U.S. Constitution that would cut back on child labor.NellieTaloeRossWYgovernor.jpg These ideas all came from solid, Progressive thinking. But Nellie was the first governor to back them in Wyoming.She lost her reelection, but kept plenty busy turning out the women’s vote for FDR and spending 20 years as the first woman director of the U.S. Mint.  Died at 101, her life spanning presidents Grant through Carter.  Currently four of our ten sitting female governors are Republican.  But Ross was first. And as with so many firsts in politics and civil rights, the letter next to her name was a big ol’ D.–BRIEF SANITY BREAK––END BRIEF SANITY BREAK–JEERS to a supreme nuisance. Until the administration of 46th president Joseph R. Biden (we hiope) is able to enhance and re-balance the makeup of the Supreme Court, we’re going to have to deal with days like today, when six of the nine are going to insist that Americans who happen to be L, G,B, T, or Q are second-class citizens. And we’re going to have to sit here and take it for now…The Supreme Court is set to hear a case concerning the rights of gay and lesbian Americans on Wednesday morning in a dispute that advocates are warning could pierce holes in the nation’s anti-discrimination laws. […]Interior of US Supreme Court in Washington DC.Because of Covid, today’s SCOTUS event will likely be held virtually again. But it’ll still be just as infuriating.Religious rights activists are pushing for the court to use the case, Fulton v. City of Philadelphia, to overturn a 30-year-old precedent that has for decades mediated the balance between freedom of conscience and the rights of minority groups. Doing so could effectively reverse the court’s trend in recent years of advancing protections for LGBT people, civil rights advocates warn. The case could also weaken laws protecting other groups, including Jews, Muslims and Mormons.The case concerns a Roman Catholic adoption agency in Philadelphia that claims that it can’t match foster children with same-sex households without violating its religious beliefs.The court will look a little different today, thanks to last week’s partisan Senate vote confirming the latest member and restoring it to its full nine-member complement. So now it’ll be Roberts, Thomas, Kagan, Souter, Alito, Kavanaugh, Sotomayor, Gorsuch, and some crazy lady shouting Bible verses while drowning a kitten in bucket.CHEERS to a very bad day for the GOP.  Eighty-four years ago today, on November 4th, 1936, the media was blaring the news that FDR had been re-elected in a landslide over Alf Landon by—get this—523 electoral votes to 8:Rooseveltlandslide1936washingtonpost.jpg Percent increase in Covid-19 deaths (238,000 now) over the last two weeks: 15%Number of states that don’t have some kind of mask mandate in place: 2 (ND, SD)Rank of Belgium among top Covid-19 hot spots in Europe: #1- Advertisement – – Advertisement – On this date twenty-eight years later, the papers trumpeted Lyndon Johnson’s victory over Barry Goldwater 486-52.  Twenty-eight years after that Bill Clinton dispatched George H.W. Bush by a less-substantial but still impressive 370-168 margin. And 16 years after that, Barack Obama disposed of John McCain 365-173. Grand total: 1,754 to 303.  Takeaway message: revenge is a dish best served lopsided.–Ten years ago in C&J: November 4, 2010JEERS to the new bully on the block.  38 percent of the 50 percent of Mainers who turned out to vote Tuesday—representing about, oh, twenty percent of all Mainers who live here—was all it took to get a teabagger installed in the governor’s mansion here.  Oh, and we also lost control of both the House and Senate for the first time since 1974.  So off we go into a new era of austerity and nuclear plants and creationism taught as science and, golly, who knows what else.  As of January first we’re changing our state motto: Welcome to Maine—The Alabama of the Northeast.  Yeehaw!  [11/4/20 Update: Our legislature is controlled by Democrats again and our governor is a super-competent and popular Democratic woman, and all is well in the state of Maine.]–And just one more…CHEERS to a fond farewell. I don’t know what he plans to do between now and January, but one thing I hope comes to pass in 77 days: he’s gonna be gone, gone, glug glug glug gone…And the band can play one final rendition of Nearer My Future Jail Cell to Thee.Have a happy humpday. Floor’s open…What are you cheering and jeering about today?–Today’s Shameless C&J TestimonialTrump Assures Daily Kos He’ll Fire Bill in Portland Maine After The Election—Wonkette–last_img read more

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Man U about town

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PREMIUMBKPM opens command center to speed up license issuance

first_imgFacebook Log in with your social account Google Topics : Forgot Password ? Linkedin LOG INDon’t have an account? Register here The Investment Coordinating Board (BKPM) has launched a command center to monitor the issuance of licenses in related government offices and help the board expedite the process.The Command Center for the Operation and Monitoring of Investment, which was launched on Monday, provides real-time information regarding the issuance of licenses to investors. This includes daily statistics of license issuance, recapitulation of license issuance by ministries and companies’ end-to-end licensing status, BKPM chairman Bahlil Lahadalia said during an online press conference that followed the opening of the center.“With this command center, we can determine the problems in the issuance of the licenses. Insya Allah [God Willing] with our new authorities, BKPM will improve the speed, certainty and efficiency of licensing processes,” he said at the command center in Jakarta…. Indonesia investment BKPM command-center Bahlil-Lahadalia realization China COVID-19last_img read more

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Wall That Heals in Indiana this week

first_imgGreenfield, IN—The Wall That Heals has been displayed in nearly 600 communities throughout the nation, spreading the memorial’s healing legacy to millions.The Wall That Heals is a three-quarter-scale replica of the Vietnam Veteran Memorial that is designed to travel to communities throughout the United States.  Its only stop in Indiana this year will be in Greenfield from July 11 thru 14 at Stillinger Family Funeral Home starting at 12:01 am.last_img

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Cricket News After New Zealand series win, how can Indian cricket team become No.1 in ODIs?

first_img New Delhi: India have ended their ODI series Down Under on the ultimate high. After securing a bilateral series win over Australia for the first time, the Indian cricket team eliminated 10 years of pain by winning the five-match ODI series against New Zealand. The 4-1 scoreline is India’s best-ever in the country in any format ever since they started touring the country in 1967. In the ICC ODI team rankings for 2019, England remain in top spot with 126 points followed by India who are second with 122 points while there is a 11-point gap between India and South Africa who are third on 111 points.With the ICC Cricket World Cup just three months away, the number of bilateral ODI series reduces with each week. After India’s tour of New Zealand, they play just the five ODIs and two Twenty20 Internationals against Australia. England play five ODIs against West Indies while South Africa play Sri Lanka. After the series against India, Australia will square off in a five-match series against Pakistan. The five matches against Australia is India’s last chance before the World Cup. What must they do in order to become the No.1 ranked ODI side in the world? India will take on Australia at home for five ODIs before the World Cup.India secured bilateral series wins in Australia and New Zealand.India need to win the series 4-1 or 5-0 and hope West Indies beat England. highlights For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps. Basically, India has to win the five-match series against Australia 4-1 or 5-0 and hope West Indies win the series against England 3-2. A 3-2,4-1 or 5-0 win for West Indies against England will ensure India remain on top with a good lead. For England, if they win the series 4-1, they must hope Australia wins one of their games against India. If England win the series 3-2 and India secure a 4-1 or 5-0 series against Australia, then Virat Kohli’s side will be the No.1.The current ICC individual rankings for batsmen and bowlers is currently led by Virat Kohli and Jasprit Bumrah respectively. Kohli smashed a century in Adelaide but Bumrah was rested for the entire ODIs against Australia and in the series against New Zealand. Trent Boult moved up one place to third after his wonderful haul of 5/21 in Hamilton and for his good haul in Wellington.last_img read more

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